Article

Blood cells of BRCA1 mutation and epimutation carries appear to acquire specific epigenetic signatures

2025-08-12

Abstract excerpt

<title>Abstract</title> <p> Background We and others have shown that a <italic>BRCA1</italic> epimutation detectable in blood is associated with an elevated risk of breast cancer, particularly triple-negative breast cancer, similarly as <italic>BRCA1</italic> germline mutations. However, the effect of <italic>BRCA1</italic> epimutation as well as germline mutations on the methylomes of carriers has not bee...

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Literature Corpus work: 722f1b74-5ed6-5dba-a135-91c48b3bb601
DOI: 10.21203/rs.3.rs-7301339/v1

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