Article

Cell-type-specific epigenomic variations associated with <i>BRCA1</i> mutation in pre-cancer human breast tissues

2020-08-24

Abstract excerpt

BRCA1 germline mutation carriers are predisposed to breast cancers. Epigenomic regulations have been known to strongly interact with genetic variations and potentially mediate biochemical cascades involved in tumorigenesis. Due to the cell-type specificity of epigenomic features, profiling of individual cell types is critical for understanding the molecular events in various cellular compartments within complex br...

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Literature Corpus work: 07f6327d-18e1-5031-9aa8-9d4891b016f5
DOI: 10.1101/2020.08.24.265199

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