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Article

Estrogen receptor-positive, BRCA1-deficient breast cancer: BRCA1-epimutated tumors presenting a piece to the puzzle.

Breast cancer research : BCR - 17 Apr 2026

Lønning Per E, Nikolaienko Oleksii, Knappskog Stian

Abstract excerpt

While the majority of breast cancers arising in women with germline BRCA1 pathogenic variants (gBRCA1) are triple-negative (TNBC), these women also have a moderately increased risk of ER+ breast cancers. The contribution of BRCA1 deficiency to the development of ER+ breast cancers in gBRCA1 carriers is incompletely understood. BRCA1 epimutations (promoter hypermethylation) have emerged as a major factor in TNBC....

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Share to BRCA1 Protein
Share to Breast Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Germ-Line Mutation

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Share to Receptors, Estrogen

Share to Triple Negative Breast Neoplasms

Source

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Identifiers

PMID: 41998785
DOI: 10.1186/s13058-026-02279-8
PMCID: PMC13227890

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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