Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers.

Nature communications - 27 Jul 2020

Glodzik Dominik, Bosch Ana, Hartman Johan, Aine Mattias, Vallon-Christersson Johan, Reuterswärd Christel, Karlsson Anna, Mitra Shamik, Niméus Emma, Holm Karolina, Häkkinen Jari, Hegardt Cecilia, Saal Lao H, Larsson Christer, Malmberg Martin, Rydén Lisa, Ehinger Anna, Loman Niklas, Kvist Anders, Ehrencrona Hans, Nik-Zainal Serena, Borg Åke, Staaf Johan

Abstract excerpt

Homologous recombination deficiency (HRD) is a defining characteristic in BRCA-deficient breast tumors caused by genetic or epigenetic alterations in key pathway genes. We investigated the frequency of BRCA1 promoter hypermethylation in 237 triple-negative breast cancers (TNBCs) from a population-based study using reported whole genome and RNA sequencing data, complemented with analyses of genetic, epigenetic,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B7-H1 Antigen
Share to BRCA1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to DNA Methylation

Share to Gene Expression Regulation, Neoplastic

Share to Transcription, Genetic

Share to Treatment Outcome

Share to Triple Negative Breast Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 32719340
DOI: 10.1038/s41467-020-17537-2
PMCID: PMC7385112

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers.PMID 32719340Read ↗

BRCA1 deficiency is a recurrent event in early-onset triple-negative breast cancer: a comprehensive analysis of germline mutations and somatic promoter methylationSemantic proximity Read ↗

The DNA methylation landscape of primary triple-negative breast cancerSemantic proximity Read ↗

BRCA1 promoter methylation in peripheral blood is associated with the risk of triple‐negative breast cancerSemantic proximity Read ↗

DNA methylation and immune evasion in triple-negative breast cancer: challenges and therapeutic opportunitiesSemantic proximity Read ↗

Genome-wide DNA methylation profiling in triple-negative breast cancer reveals epigenetic signatures with important clinical valueSemantic proximity Read ↗

Association of tumor immune infiltration and prognosis with homologous recombination repair genes mutations in early triple-negative breast cancer.Semantic proximity Read ↗

Integrative analysis of genomic alterations in triple-negative breast cancer in association with homologous recombination deficiency.Semantic proximity Read ↗

Gene expression signature for predicting homologous recombination deficiency in triple-negative breast cancerSemantic proximity Read ↗

DNA Methylation Signatures in Breast Cancer: A Systematic Review and Meta-AnalysisSemantic proximity Read ↗

Molecular intrinsic subtypes, genomic, and immune landscapes of BRCA-proficient but HRD-high ER-positive/HER2-negative early breast cancersSemantic proximity Read ↗

Molecular intrinsic subtypes, genomic and immune landscapes of BRCA-proficient but HRD-high ER-positive/HER2-negative early breast cancersSemantic proximity Read ↗

Estrogen receptor-positive, BRCA1-deficient breast cancer: BRCA1-epimutated tumors presenting a piece to the puzzle.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.