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Prenatal BRCA1 epimutations contribute significantly to triple-negative breast cancer development

6 Dec 2023

Abstract excerpt

BACKGROUND: Normal cell BRCA1 epimutations have been associated with increased risk of triple-negative breast cancer (TNBC). However, the fraction of TNBCs that may have BRCA1 epimutations as their underlying cause is unknown. Neither are the time of occurrence and the potential inheritance patterns of BRCA1 epimutations established. METHODS: To address these questions, we analyzed BRCA1 methylation status in...

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PMID: 38053165
DOI: 10.1186/s13073-023-01262-8

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