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Methylation of BRCA1 and MGMT genes in white blood cells are transmitted from mothers to daughters

26 Jul 2018

Abstract excerpt

BACKGROUND: Constitutive methylation of tumor suppressor genes are associated with increased cancer risk. However, to date, the question of epimutational transmission of these genes remains unresolved. Here, we studied the potential transmission of BRCA1 and MGMT promoter methylations in mother-newborn pairs. METHODS: A total of 1014 female subjects (cancer-free women, n = 268; delivering women, n = 295; newborn...

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PMID: 30049288
DOI: 10.1186/s13148-018-0529-5

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