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Article

Constitutive promoter methylation of BRCA1 and RAD51C in patients with familial ovarian cancer and early-onset sporadic breast cancer.

Human molecular genetics - 1 Nov 2012

Hansmann Tamara, Pliushch Galyna, Leubner Monika, Kroll Patricia, Endt Daniela, Gehrig Andrea, Preisler-Adams Sabine, Wieacker Peter, Haaf Thomas

Abstract excerpt

Genetic defects in breast cancer (BC) susceptibility genes, most importantly BRCA1 and BRCA2, account for ~40% of hereditary BC and ovarian cancer (OC). Little is known about the contribution of constitutive (soma-wide) epimutations to the remaining cases. We developed bisulfite pyrosequencing assays to screen >600 affected BRCA1/BRCA2 mutation-negative patients from the German Consortium for Hereditary Breast...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cell Transformation, Neoplastic

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Source

Open in PubMed Open full text

Identifiers

PMID: 22843497
DOI: 10.1093/hmg/dds308
PMCID: PMC3471399

Genes

BRCA1
BRCA2
ATM
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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