Article

Enhancer and super-enhancer landscape in polycystic kidney disease

2021-11-19

Abstract excerpt

<h4>ABSTRACT</h4> Widespread aberrant gene expression is pathological hallmark of polycystic kidney disease (PKD). Numerous pathogenic signaling cascades, including c-Myc, Fos, and Jun are transactivated. However, the underlying epigenetic regulators are poorly defined. Here we show that H3K27ac, a histone modification that marks active enhancers, is elevated in mouse and human ADPKD samples. Using comparative H3...

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Literature Corpus work: 5211d86e-e0ba-5a66-9d3e-f0661cfdac3e
DOI: 10.1101/2021.11.19.469306

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