Article

Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis

2021-10-22

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is the leading genetic cause of end stage renal disease and is characterized by the formation and progressive expansion of kidney cysts. Most ADPKD cases arise from mutations in either the PKD1 or PKD2 gene but the precise downstream signaling pathways driving cyst growth are not well understood, and relatively few studies investigate human cystic kidney due t...

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Literature Corpus work: d913e84a-1f46-501a-ae75-81fdc2a7b2cf
DOI: 10.1101/2021.10.21.465323

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