Article

Chaperone quality control in liquid-phase separated organelles

2024-01-23

Abstract excerpt

<h4>Summary</h4> Molecular chaperones, central to the cellular proteostasis network, play an essential role in preventing the formation and proliferation of harmful aggregates associated with neurodegenerative diseases. Notably, for many intrinsically disordered proteins (IDPs), which are prone to form such damaging deposits, the formation of nano-clusters and phase separation into organelles prior to aggregation...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 06f5ae05-409a-5f88-9424-d597b0598cf8
DOI: 10.1101/2024.01.23.576883

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Chaperone quality control in liquid-phase separated organellesDOI 10.1101/2024.01.23.576883Read

Nuclear bodies protect phase separated proteins from degradation in stressed proteomeSemantic proximity Read

Sequestration of TDP-43 <sup>216-414</sup> aggregates by cytoplasmic expression of the proSAAS chaperoneSemantic proximity Read

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation.Semantic proximity Read

Chaperone-mediated heterotypic phase separation prevents the amyloid formation of the pathological Y145Stop variant of the prion proteinSemantic proximity Read

HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA binding domainSemantic proximity Read

Liquid-liquid phase separation induces pathogenic tau conformations in vitro.Semantic proximity Read

ALS-causing hPFN1 mutants differentially disrupt LLPS of FUS prion-like domain.Semantic proximity Read

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separationSemantic proximity Read

Molecular Mechanisms of Protein Aggregation in ALS-FTD: Focus on TDP-43 and Cellular Protective ResponsesSemantic proximity Read

Liquid-liquid phase separation and aggregation of a globular folded protein SUMO1Semantic proximity Read

AgDD System: A Chemical Controllable Protein Aggregates in Cells.Semantic proximity Read

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid–liquid phase separationSemantic proximity Read