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The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid–liquid phase separation

28 Jun 2021

Abstract excerpt

Liquid-liquid phase separation (LLPS) of proteins and RNAs has emerged as the driving force underlying the formation of membrane-less organelles. Such biomolecular condensates have various biological functions and have been linked to disease. The protein Fused in Sarcoma (FUS) undergoes LLPS and mutations in FUS have been causally linked to the motor neuron disease Amyotrophic Lateral Sclerosis (ALS-FUS). LLPS...

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PMID: 34233002
DOI: 10.1093/nar/gkab582

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