Article

Small heat shock proteins HspB1 and HspB5 differentially alter the condensation and aggregation of the TDP-43 low complexity domain

2025-09-18

Abstract excerpt

TAR DNA-binding protein 43 (TDP-43) is a nucleic acid-binding protein that regulates processes of mRNA metabolism, during which it undergoes condensation mediated by its C-terminal low complexity domain (TDP-43 LCD ). TDP-43 aggregation and condensation are associated with neurodegenerative disease. However, the proteostasis mechanisms that regulate these processes remain elusive. Some evidence has shown that the...

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Literature Corpus work: f0b6d7c1-5c62-58b6-8641-cd8e766eda7e
DOI: 10.1101/2025.09.17.672772

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