Article

Biparatopic sybody constructs neutralize SARS-CoV-2 variants of concern and mitigate emergence of drug resistance

2020-11-10

Abstract excerpt

<h4>ABSTRACT</h4> The ongoing COVID-19 pandemic represents an unprecedented global health crisis. Here, we report the identification of a synthetic nanobody (sybody) pair (Sb#15 and Sb#68) that can bind simultaneously to the SARS-CoV-2 spike-RBD and efficiently neutralize pseudotyped and live-viruses by interfering with ACE2 interaction. Two spatially-discrete epitopes identified by cryo-EM translated into the ra...

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Identifiers and source

Literature Corpus work: 51fefdd8-9ced-575e-a65c-38e16c192816
DOI: 10.1101/2020.11.10.376822

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