Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape.

doi:10.1126/science.abe6230

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Article

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape.

Science (New York, N.Y.) - 12 Feb 2021

Koenig Paul-Albert, Das Hrishikesh, Liu Hejun, Kümmerer Beate M, Gohr Florian N, Jenster Lea-Marie, Schiffelers Lisa D J, Tesfamariam Yonas M, Uchima Miki, Wuerth Jennifer D, Gatterdam Karl, Ruetalo Natalia, Christensen Maria H, Fandrey Caroline I, Normann Sabine, Tödtmann Jan M P, Pritzl Steffen, Hanke Leo, Boos Jannik, Yuan Meng, Zhu Xueyong, Schmid-Burgk Jonathan L, Kato Hiroki, Schindler Michael, Wilson Ian A, Geyer Matthias, Ludwig Kerstin U, Hällberg B Martin, Wu Nicholas C, Schmidt Florian I

Abstract excerpt

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread, with devastating consequences. For passive immunization efforts, nanobodies have size and cost advantages over conventional antibodies. In this study, we generated four neutralizing nanobodies that target the receptor binding domain of the SARS-CoV-2 spike protein. We used x-ray crystallography and...

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Identifiers

PMID: 33436526
DOI: 10.1126/science.abe6230
PMCID: PMC7932109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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