Article

A Potent Bispecific Nanobody Protects hACE2 Mice Against SARS-CoV-2 Infection via Intranasal Administration

2021-04-23

Abstract excerpt

The dramatically expanding COVID-19 needs multiple effective countermeasures. Neutralizing nanobodies (Nbs) are a potential therapeutic strategy for treating COVID-19. Here, we characterized several RBD-specific Nbs isolated from an Nb library derived from an alpaca immunized with SARS-CoV-2 spike glycoprotein (S); among them, three Nbs exhibited picomolar potency against SARS-CoV-2 live virus, pseudotyped viruse...

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Literature Corpus work: 78e2acb8-72d2-5b4e-955d-2e8f491b84d5
DOI: 10.2139/ssrn.3832975

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