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Biparatopic sybodies neutralize SARS‐CoV‐2 variants of concern and mitigate drug resistance

7 Mar 2022

Abstract excerpt

The ongoing COVID-19 pandemic represents an unprecedented global health crisis. Here, we report the identification of a synthetic nanobody (sybody) pair, Sb#15 and Sb#68, that can bind simultaneously to the SARS-CoV-2 spike RBD and efficiently neutralize pseudotyped and live viruses by interfering with ACE2 interaction. Cryo-EM confirms that Sb#15 and Sb#68 engage two spatially discrete epitopes, influencing...

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PMID: 35253970
DOI: 10.15252/embr.202154199

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