Article

Versatile, Multivalent Nanobody Cocktails Efficiently Neutralize SARS-CoV-2

2020-08-24

Abstract excerpt

The outbreak of COVID-19 has severely impacted global health and the economy. Cost-effective, highly efficacious therapeutics are urgently needed. Here, we used camelid immunization and proteomics to identify a large repertoire of highly potent neutralizing nanobodies (Nbs) to the SARS-CoV-2 spike (S) protein receptor-binding domain (RBD). We discovered multiple elite Nbs with picomolar to femtomolar affinities th...

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Literature Corpus work: 5a1fc847-ad2f-5477-a2e6-c446f26cb69b
DOI: 10.1101/2020.08.24.264333

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