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Article

Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies.

The EMBO journal - 1 Oct 2021

Güttler Thomas, Aksu Metin, Dickmanns Antje, Stegmann Kim M, Gregor Kathrin, Rees Renate, Taxer Waltraud, Rymarenko Oleh, Schünemann Jürgen, Dienemann Christian, Gunkel Philip, Mussil Bianka, Krull Jens, Teichmann Ulrike, Groß Uwe, Cordes Volker C, Dobbelstein Matthias, Görlich Dirk

Abstract excerpt

Monoclonal anti-SARS-CoV-2 immunoglobulins represent a treatment option for COVID-19. However, their production in mammalian cells is not scalable to meet the global demand. Single-domain (VHH) antibodies (also called nanobodies) provide an alternative suitable for microbial production. Using alpaca immune libraries against the receptor-binding domain (RBD) of the SARS-CoV-2 Spike protein, we isolated 45...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34302370
DOI: 10.15252/embj.2021107985
PMCID: PMC8420576

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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