Article

ARF6-AMAP1 pathway induces pancreatic cancer cells to express immunosuppressive chemokines

2022-08-01

Abstract excerpt

<h4>Aim: </h4> The tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) is highly immune suppressive with modest T-cell infiltration, and only rarely responds to immune checkpoint inhibition (ICI) therapy. Our aim was to clarify the molecular basis underlying the immune suppressive properties of PDAC. <h4>Background: </h4> Mutations in both KRAS and TP53 genes are characteristic of PDAC. A major...

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Identifiers and source

Literature Corpus work: 51e402f8-febb-5dd3-a4c5-4f78805d0ff6
DOI: 10.21203/rs.3.rs-1897319/v1

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