Article
A Four-Chemokine Signature Is Associated with a T-cell-Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2020
Romero Joan M, Grünwald Barbara, Jang Gun-Ho, Bavi Prashant P, Jhaveri Aaditeya, Masoomian Mehdi, Fischer Sandra E, Zhang Amy, Denroche Robert E, Lungu Ilinca M, De Luca Angela, Bartlett John M S, Xu Jing, Li Niandong, Dhaliwal Sharon, Liang Sheng-Ben, Chadwick Dianne, Vyas Foram, Bronsert Peter, Khokha Rama, McGaha Tracy L, Notta Faiyaz, Ohashi Pamela S, Done Susan J, O'Kane Grainne M, Wilson Julie M, Knox Jennifer J, Connor Ashton, Wang Yifan, Zogopoulos George, Gallinger Steven
Abstract excerpt
PURPOSE: The molecular drivers of antitumor immunity in pancreatic ductal adenocarcinoma (PDAC) are poorly understood, posing a major obstacle for the identification of patients potentially amenable for immune-checkpoint blockade or other novel strategies. Here, we explore the association of chemokine expression with effector T-cell infiltration in PDAC. EXPERIMENTAL DESIGN: Discovery cohorts comprised 113...
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