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Article

Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially regulate T-cell phenotype and function.

Journal of immunology (Baltimore, Md. : 1950) - 7 Jun 2026

Maru Saumya Y, Wetzel Meredith, Mitchell Jacob T, Gross Nicole E, Andaloori Lalitya, Howe Kathryn, Kartalia Emma, Mo Guanglan, Leatherman James, Ho Won Jin, Fertig Elana J, Kagohara Luciane T, Pearce Edward J, Jaffee Elizabeth M

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is characterized by an immunosuppressive tumor microenvironment (TME) in which cancer-associated fibroblasts (CAFs) play pivotal roles in shaping therapeutic responses. Among these, MHC-II-expressing antigen-presenting CAFs (apCAFs) modulate CD4 T-cell activity, yet their contribution to the antitumor immune response remains unclear. Using tumor clones of the KPC murine...

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Share to Cancer-Associated Fibroblasts
Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Immune Checkpoint Inhibitors

Share to Mice, Inbred C57BL

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Source

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Identifiers

PMID: 42373588
DOI: 10.1093/jimmun/vkag165
PMCID: PMC13314266

Genes

CD4
CCL22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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