Article

Blockades Adenosine Receptor 2B Suppresses Pancreatic Adenocarcinoma Progression by Inhibiting Leukemia Inhibitory Factor Secretion from Macrophages

2024-10-11

Abstract excerpt

<title>Abstract</title> <p>Background Pancreatic adenocarcinoma (PDAC) is a lethal disease with a five-year survival rate of less than 10%. The immunosuppressive tumor microenvironment (TME) was primarily responsible for the poor prognosis in PDAC. M2 Macrophages are a crucial cell population with pro-tumorigenic effects in response to extrinsic signals. Adenosine, a purine nucleoside catabolite of ATP, is one o...

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Literature Corpus work: 7db94de9-5609-56eb-b11e-9392e5029412
DOI: 10.21203/rs.3.rs-4829619/v1

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