Article

Carboxylesterase 1 genetic variability, expression and potential for drug-drug interactions

2014-01-01

Abstract excerpt

Carboxylesterase 1 (CES1) is the main human liver esterase and is involved in the metabolism and disposition of numerous endogenous and pharmacological compounds. Some of the substrates of this enzyme are widely prescribed agents such as clopidogrel (Plavix®), methylphenidate (Ritalin®) and oseltamivir (Tamiflu®). However, there is much uncertainty regarding the genetic variability within CES1, and its regulation...

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Literature Corpus work: 51cde92a-d95c-5f0b-ba9b-24153255b38e
DOI: 10.17638/02006752

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