Article

HotSPOT: a computational tool to design targeted sequencing panels to assess early photocarcinogenesis

2022-12-05

Abstract excerpt

Mutations found in skin are acquired in specific patterns, clustering around mutation-prone genomic locations. The most mutation-prone genomic areas, mutation hotspots, first induce the growth of small cell clones in healthy skin. Mutations accumulate over time, and driver mutation clones may give rise to skin cancer. Early mutation accumulation is a crucial first step in photocarcinogenesis. Therefore, a sufficie...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 51bdea77-cca3-5eb7-b7cd-564df5801ed3
DOI: 10.21203/rs.3.rs-2216887/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HotSPOT: a computational tool to design targeted sequencing panels to assess early photocarcinogenesisDOI 10.21203/rs.3.rs-2216887/v1Read

Selection of Oncogenic Mutant Clones in Normal Human Skin Varies with Body Site.Semantic proximity Read

The genomic landscapes of individual melanocytes from human skinSemantic proximity Read

Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin.Semantic proximity Read

Pervasive Induction of Regulatory Mutation Microclones in Sun-exposed SkinSemantic proximity Read

Ultra-deep sequencing differentiates patterns of skin clonal mutations associated with sun-exposure status and skin cancer burdenSemantic proximity Read

The genomic landscapes of individual melanocytes from human skin.Semantic proximity Read

The effect of age on the acquisition and selection of cancer driver mutations in sun-exposed normal skin.Semantic proximity Read

Ultradeep sequencing differentiates patterns of skin clonal mutations associated with sun-exposure status and skin cancer burden.Semantic proximity Read

Mutational Landscape of Normal Human Skin: Clues to Understanding Early-Stage Carcinogenesis in Keratinocyte Neoplasia.Semantic proximity Read

Shedding Light on Mutant Clonal Dynamics and Cancer Risk in the Skin.Semantic proximity Read

Genomic sites hypersensitive to ultraviolet radiation.Semantic proximity Read

Transposon mutagenesis identifies cooperating genetic drivers during keratinocyte transformation and cutaneous squamous cell carcinoma progressionSemantic proximity Read