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Transposon mutagenesis identifies cooperating genetic drivers during keratinocyte transformation and cutaneous squamous cell carcinoma progression

2019-12-26

Abstract excerpt

The systematic identification of genetic events driving cellular transformation and tumor progression in the absence of a highly recurrent oncogenic driver mutation is a challenge in cutaneous oncology. In cutaneous squamous cell carcinoma (cuSCC), the high UV-induced mutational burden poses a hurdle to achieve a complete molecular landscape of this disease. Here, we utilized the Sleeping Beauty transposon mutage...

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Identifiers and source

Literature Corpus work
d5239fdf-12fd-5728-951b-af2424007ffc
DOI
10.1101/2019.12.24.887968
Open publication

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Transposon mutagenesis identifies cooperating genetic drivers during keratinocyte transformation and cutaneous squamous cell carcinoma progressionDOI 10.1101/2019.12.24.887968
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