Article

Pervasive Induction of Regulatory Mutation Microclones in Sun-exposed Skin

2024-09-16

Abstract excerpt

Carcinogen-induced mutations are thought near-random, with rare cancer-driver mutations underlying clonal expansion. Using high-fidelity Duplex Sequencing to reach a mutation frequency sensitivity of 4×10 -9 per nt, we report that sun exposure creates pervasive mutations at sites with ∼100-fold UV-sensitivity in RNA-processing gene promoters – cyclobutane pyrimidine dimer (CPD) hyperhotspots – and these mutations...

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Literature Corpus work: 698548c1-024a-50c5-a835-eacfcc3877e1
DOI: 10.1101/2024.09.12.612526

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