Article
Ultradeep sequencing differentiates patterns of skin clonal mutations associated with sun-exposure status and skin cancer burden.
Science advances - 1 Jan 2021
Wei Lei, Christensen Sean R, Fitzgerald Megan E, Graham James, Hutson Nicholas D, Zhang Chi, Huang Ziyun, Hu Qiang, Zhan Fenglin, Xie Jun, Zhang Jianmin, Liu Song, Remenyik Eva, Gellen Emese, Colegio Oscar R, Bax Michael, Xu Jinhui, Lin Haifan, Huss Wendy J, Foster Barbara A, Paragh Gyorgy
Abstract excerpt
In ultraviolet (UV) radiation-exposed skin, mutations fuel clonal cell growth. The relationship between UV exposure and the accumulation of clonal mutations (CMs) and the correlation between CMs and skin cancer risk are largely unexplored. We characterized 450 individual-matched sun-exposed (SE) and non-SE (NE) normal human skin samples. The number and relative contribution of CMs were significantly different...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.