Article
The genomic landscapes of individual melanocytes from human skin.
Nature - 1 Oct 2020
Tang Jessica, Fewings Eleanor, Chang Darwin, Zeng Hanlin, Liu Shanshan, Jorapur Aparna, Belote Rachel L, McNeal Andrew S, Tan Tuyet M, Yeh Iwei, Arron Sarah T, Judson-Torres Robert L, Bastian Boris C, Shain A Hunter
Abstract excerpt
Every cell in the human body has a unique set of somatic mutations, but it remains difficult to comprehensively genotype an individual cell1. Here we describe ways to overcome this obstacle in the context of normal human skin, thus offering a glimpse into the genomic landscapes of individual melanocytes from human skin. As expected, sun-shielded melanocytes had fewer mutations than sun-exposed melanocytes....
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