Article

Autosomal Allelic Inactivation: Variable Replication and Dosage Sensitivity

2025-08-15

Abstract excerpt

Autosomal monoallelic gene expression and asynchronous replication between alleles are established features of imprinted genes and genes regulated by allelic exclusion. Inactivation/Stability Centers (I/SCs) are recently described autosomal loci that exhibit epigenetic regulation of allelic expression and replication timing, with differences that can be comparable to those observed between the active and inactive...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5188d6e6-9e84-5412-8712-042efc889f8a
DOI: 10.1101/2025.08.13.670061

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Autosomal Allelic Inactivation: Variable Replication and Dosage SensitivityDOI 10.1101/2025.08.13.670061Read

Autosomal allelic inactivation at loci with variable replication timing and dosage sensitivity.Semantic proximity Read

Autosomal monoallelic expression: genetics of epigenetic diversity?Semantic proximity Read

DNA methylation is a key mechanism for maintaining monoallelic expression on autosomesSemantic proximity Read

RNA sequencing-based screen for reactivation of silenced alleles of autosomal genes.Semantic proximity Read

Allele-specific control of replication timing and genome organization during development.Semantic proximity Read

Random monoallelic expression of autosomal genes: stochastic transcription and allele-level regulation.Semantic proximity Read

Epigenetic Control of Hundreds of Chromosome-Associated lncRNA Genes Essential for Replication and StabilitySemantic proximity Read

Dynamics of gene silencing during X inactivation using allele-specific RNA-seq.Semantic proximity Read

Locus specific epigenetic modalities of random allelic expression imbalanceSemantic proximity Read

Replication timing properties within the mouse distal chromosome 7 imprinting cluster.Semantic proximity Read

Parent-of-origin-specific DNA replication timing is confined to large imprinted regions.Semantic proximity Read

Analysis of expressed SNPs identifies variable extents of expression from the human inactive X chromosome.Semantic proximity Read