Article

DNA methylation is a key mechanism for maintaining monoallelic expression on autosomes

2020-02-21

Abstract excerpt

In diploid cells, maternal and paternal copies of genes usually have similar transcriptional activity. Mammalian allele-specific epigenetic mechanisms such as X-chromosome inactivation (XCI) and imprinting were historically viewed as rare exceptions to this rule. The discovery of mitotically stable monoallelic autosomal expression (MAE) a decade ago revealed an additional allele-specific mode regulating thousands...

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Literature Corpus work: 42c967d7-462b-550a-9138-b317e6fa403d
DOI: 10.1101/2020.02.20.954834

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