Article
RNA sequencing-based screen for reactivation of silenced alleles of autosomal genes.
G3 (Bethesda, Md.) - 4 Feb 2022
Gupta Saumya, Lafontaine Denis L, Vigneau Sebastien, Mendelevich Asia, Vinogradova Svetlana, Igarashi Kyomi J, Bortvin Andrew, Alves-Pereira Clara F, Nag Anwesha, Gimelbrant Alexander A
Abstract excerpt
In mammalian cells, maternal and paternal alleles usually have similar transcriptional activity. Epigenetic mechanisms such as X-chromosome inactivation (XCI) and imprinting were historically viewed as rare exceptions to this rule. Discovery of autosomal monoallelic autosomal expression (MAE) a decade ago revealed an additional allele-specific mode regulating thousands of mammalian genes. Despite MAE prevalence,...
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