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Article

Autosomal allelic inactivation at loci with variable replication timing and dosage sensitivity.

eLife - 8 Jul 2026

Heskett Michael B, Vouzas Athanasios E, Johnstone Brian, Freese Krister P, Yates Phillip A, Copenhaver Philip F, Spellman Paul T, Gilbert David M, Thayer Mathew J

Abstract excerpt

Autosomal monoallelic gene expression and asynchronous replication between alleles are established features of imprinted genes and genes regulated by allelic exclusion. Inactivation/Stability Centers (I/SCs) are recently described autosomal loci that exhibit epigenetic regulation of allelic expression and replication timing, with differences that can be comparable to those observed between the active and inactive...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42417611
DOI: 10.7554/eLife.109938
PMCID: PMC13345637

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