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Article

Parent-of-origin-specific DNA replication timing is confined to large imprinted regions.

Cell reports - 24 Sept 2024

Edwards Matthew M, Wang Ning, Sagi Ido, Kinreich Shay, Benvenisty Nissim, Gerhardt Jeannine, Egli Dieter, Koren Amnon

Abstract excerpt

Genomic imprinting involves differential DNA methylation and gene expression between homologous paternal and maternal loci. It remains unclear, however, whether DNA replication also shows parent-of-origin-specific patterns at imprinted or other genomic regions. Here, we investigate genome-wide asynchronous DNA replication utilizing uniparental human embryonic stem cells containing either maternal-only...

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PMID: 39235941
DOI: 10.1016/j.celrep.2024.114700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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