Article
Replication timing properties within the mouse distal chromosome 7 imprinting cluster.
Bioscience, biotechnology, and biochemistry - 1 May 2002
Kagotani Kazuhiro, Takebayashi Shin-ichiro, Kohda Atsushi, Taguchi Hiroshi, Paulsen Martina, Walter Jörn, Reik Wolf, Okumura Katsuzumi
Abstract excerpt
Genomic imprinting is characterized by allele-specific expression of genes within chromosomal domains. Here we show, using fluorescence in situ hybridization (FISH) analysis, that the large chromosomal domain of the mouse distal chromosome 7 imprinting cluster, approximately 1 Mb in length between p57Kip2 and H19 genes, replicates asynchronously between the two alleles during S-phase. At the telomeric side of...
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