Article
Autosomal monoallelic expression: genetics of epigenetic diversity?
Current opinion in genetics & development - 1 Dec 2013
Savova Virginia, Vigneau Sébastien, Gimelbrant Alexander A
Abstract excerpt
In mammals, relative expression of the two parental alleles of many genes is controlled by one of three major epigenetic phenomena: X chromosome inactivation, imprinting, and mitotically stable autosomal monoallelic expression (MAE). MAE affects a large fraction of human autosomal genes and introduces enormous epigenetic heterogeneity in otherwise similar cell populations. Despite its prevalence, many functional...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
