Autosomal monoallelic expression: genetics of epigenetic diversity?

doi:10.1016/j.gde.2013.09.001

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Article

Autosomal monoallelic expression: genetics of epigenetic diversity?

Current opinion in genetics & development - 1 Dec 2013

Savova Virginia, Vigneau Sébastien, Gimelbrant Alexander A

Abstract excerpt

In mammals, relative expression of the two parental alleles of many genes is controlled by one of three major epigenetic phenomena: X chromosome inactivation, imprinting, and mitotically stable autosomal monoallelic expression (MAE). MAE affects a large fraction of human autosomal genes and introduces enormous epigenetic heterogeneity in otherwise similar cell populations. Despite its prevalence, many functional...

Topics

Alleles
Animals
Epigenesis, Genetic
Gene Expression
Genetic Variation
Genome
Haploinsufficiency
Humans
Models, Genetic
Regulatory Sequences, Nucleic Acid

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Open in PubMed

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PMID: 24075575
DOI: 10.1016/j.gde.2013.09.001

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