Back to search

Article

Disentangling selection on genetically correlated polygenic traits using whole-genome genealogies

2020-05-08

Abstract excerpt

We present a full-likelihood method to estimate and quantify polygenic adaptation from contemporary DNA sequence data. The method combines population genetic DNA sequence data and GWAS summary statistics from up to thousands of nucleotide sites in a joint likelihood function to estimate the strength of transient directional selection acting on a polygenic trait. Through population genetic simulations of polygenic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
51829565-11cc-55ed-a54b-886302045bd6
DOI
10.1101/2020.05.07.083402
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Disentangling selection on genetically correlated polygenic traits using whole-genome genealogiesDOI 10.1101/2020.05.07.083402
Disentangling selection on genetically correlated polygenic traits via whole-genome genealogies.Semantic proximity
A selection pressure landscape for 870 human polygenic traits.Semantic proximity
Quantification of genetic components of population differentiation in UK Biobank traits reveals signals of polygenic selectionSemantic proximity
Simple scaling laws control the genetic architectures of human complex traitsSemantic proximity
A selection pressure landscape for 870 human polygenic traitsSemantic proximity
Bayesian analysis of GWAS summary data reveals differential signatures of natural selection across human complex traits and functional genomic categoriesSemantic proximity
Mosaic patterns of selection in genomic regions associated with diverse human traitsSemantic proximity
Genetic association data are broadly consistent with stabilizing selection shaping human common diseases and traitsSemantic proximity
Mosaic patterns of selection in genomic regions associated with diverse human traits.Semantic proximity
The evolutionary genetics of polygenic diseases with the largest global burden in mortality ratesSemantic proximity
How robust are cross-population signatures of polygenic adaptation in humans?Semantic proximity
Estimating heritability and its enrichment in tissue-specific gene sets in admixed populationsSemantic proximity
Select a neighboring publication to make it the new centre.