Article

How robust are cross-population signatures of polygenic adaptation in humans?

2020-07-13

Abstract excerpt

Over the past decade, summary statistics from genome-wide association studies (GWASs) have been used to detect and quantify polygenic adaptation in humans. Several studies have reported signatures of natural selection at sets of SNPs associated with complex traits, like height and body mass index. However, more recent studies suggest that some of these signals may be caused by biases from uncorrected population st...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 842bc374-89c5-5b23-b7b8-6e74d3d9ba3a
DOI: 10.1101/2020.07.13.200030

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

How robust are cross-population signatures of polygenic adaptation in humans?DOI 10.1101/2020.07.13.200030Read

Polygenic Adaptation has Impacted Multiple Anthropometric TraitsSemantic proximity Read

A population genetic signal of polygenic adaptation.Semantic proximity Read

Signals of polygenic adaptation on height have been overestimated due to uncorrected population structure in genome-wide association studiesSemantic proximity Read

Quantification of genetic components of population differentiation in UK Biobank traits reveals signals of polygenic selectionSemantic proximity Read

A Population Genetic Signature of Polygenic Local AdaptationSemantic proximity Read

Allele frequency differentiation at height-associated SNPs among continental human populations.Semantic proximity Read

Analysis of Polygenic Score Usage and Performance in Diverse Human PopulationsSemantic proximity Read

Allele frequency differentiation at height-associated SNPs among continental human populationsSemantic proximity Read

Disentangling selection on genetically correlated polygenic traits using whole-genome genealogiesSemantic proximity Read

Signals of Human Polygenic Adaptation: Moving Beyond Single-Gene Methods and Controlling for Population-Specific Linkage DisequilibriumSemantic proximity Read

Natural selection acting on complex traits hampers the predictive accuracy of polygenic scores in ancient samples.Semantic proximity Read

Cross-Ancestry Polygenic Prediction: Comparing Methods and Assessing Transferability Across Traits.Semantic proximity Read