Article

Bayesian analysis of GWAS summary data reveals differential signatures of natural selection across human complex traits and functional genomic categories

2019-09-01

Abstract excerpt

Understanding how natural selection has shaped the genetic architecture of complex traits and diseases is of importance in medical and evolutionary genetics. Bayesian methods have been developed using individual-level data to estimate multiple features of genetic architecture, including signatures of natural selection. Here, we present an enhanced method (SBayesS) that only requires GWAS summary statistics and inc...

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Literature Corpus work: 02569824-8541-5703-9b57-4ec1607878ee
DOI: 10.1101/752527

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