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Article

cGAS deficient mice display premature aging associated with de-repression of LINE1 elements and inflammation

2024-10-11

Abstract excerpt

Aging-associated inflammation, or ‘inflammaging” is a driver of multiple age-associated diseases. Cyclic GMP-AMP Synthase (cGAS) is a cytosolic DNA sensor that functions to activate interferon response upon detecting viral DNA in the cytoplasm. cGAS contributes to inflammaging by responding to endogenous signals such as damaged DNA or LINE1 (L1) cDNA which forms in aged cells. While cGAS knockout mice are viable t...

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Identifiers and source

Literature Corpus work
51808113-b23b-5ee7-bcc1-230f01653b72
DOI
10.1101/2024.10.10.617645
Open publication

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cGAS deficient mice display premature aging associated with de-repression of LINE1 elements and inflammationDOI 10.1101/2024.10.10.617645
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