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Article

cGAS is essential for cellular senescence.

Proceedings of the National Academy of Sciences of the United States of America - 6 Jun 2017

Yang Hui, Wang Hanze, Ren Junyao, Chen Qi, Chen Zhijian J

Abstract excerpt

Cellular senescence is a natural barrier to tumorigenesis and it contributes to the antitumor effects of several therapies, including radiation and chemotherapeutic drugs. Senescence also plays an important role in aging, fibrosis, and tissue repair. The DNA damage response is a key event leading to senescence, which is characterized by the senescence-associated secretory phenotype (SASP) that includes expression...

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Identifiers

PMID: 28533362
DOI: 10.1073/pnas.1705499114
PMCID: PMC5468617

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