Article

cGAS/STING-DEPENDENT SENSING OF ENDOGENOUS RNA

2022-05-16

Abstract excerpt

Defects in nucleic acid metabolizing enzymes lead to spontaneous but selective activation of either cGAS/STING or RIG-like receptor (RLR) signaling, causing a pathogenic type I interferon response and inflammatory diseases. In these pathophysiological conditions, cGAS-driven IFN production is linked to spontaneous DNA damage. Physiological, or tonic, IFN signaling on the other hand is essential to functionally pri...

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Identifiers and source

Literature Corpus work: 1c9896b5-184b-5e4d-90cc-2632ca8eeb44
DOI: 10.1101/2022.05.16.492039

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