Article
Cytosolic DNA sensing through cGAS and STING is inactivated by gene mutations in pangolins.
Apoptosis : an international journal on programmed cell death - 1 Aug 2020
Fischer Heinz, Tschachler Erwin, Eckhart Leopold
Abstract excerpt
The release of DNA into the cytoplasm upon damage to the nucleus or during viral infection triggers an interferon-mediated defense response, inflammation and cell death. In human cells cytoplasmic DNA is sensed by cyclic GMP-AMP Synthase (cGAS) and Absent In Melanoma 2 (AIM2). Here, we report the identification of a "natural knockout" model of cGAS. Comparative genomics of phylogenetically diverse mammalian...
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