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Article

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

14 Sept 2015

Abstract excerpt

TREX1 is an exonuclease that digests DNA in the cytoplasm. Loss-of-function mutations of TREX1 are linked to Aicardi-Goutieres Syndrome (AGS) and systemic lupus erythematosus (SLE) in humans. Trex1(-/-) mice exhibit autoimmune and inflammatory phenotypes that are associated with elevated expression of interferon (IFN)-induced genes (ISGs). Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that...

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Identifiers

PMID: 26371324
DOI: 10.1073/pnas.1516465112

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