Article

Inducing aggresome and stable tau aggregation in Neuro2a cells with an optogenetic tool

2024-05-08

Abstract excerpt

Tauopathy is a spectrum of diseases characterized by fibrillary tau aggregate formation in neurons and glial cells in the brain. Tau aggregation originates in the brainstem and entorhinal cortex and then spreads throughout the brain in Alzheimer’s disease (AD), which is the most prevalent type of tauopathy. Understanding the mechanism by which locally developed tau pathology propagates throughout the brain is cruc...

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Literature Corpus work: 515ec8ee-2b1b-564b-8344-c82ee67eda90
DOI: 10.1101/2024.05.07.592868

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