Article

Optical induction of autophagy via <i>Transcription factor EB</i> (TFEB) reduces pathological tau in neurons

2019-04-05

Abstract excerpt

Aggregation and accumulation of microtubule associated protein tau in neurons is major neuropathological hallmark of Alzheimer’s disease (AD) and related tauopathies. Attempts have been made to promote clearance of pathological tau (p-Tau) from neurons via autophagy. Over expression of transcription factor EB (TFEB), has shown to clear pTau from neurons via autophagy. However, sustained TFEB activation and/or auto...

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Literature Corpus work: b10482cc-e7c0-51b5-83ff-78a7077aff32
DOI: 10.1101/600908

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