Article

Photo-excited Toluidine Blue Inhibits Full-Length Tau Aggregation in Alzheimer’ Disease

2019-07-10

Abstract excerpt

The aggregates of microtubule-associated protein Tau are the major hallmark of Alzheimer’sdisease. Tau aggregates accumulate intracellularly thus leading to generation of neuronal toxicity.Numerous approaches have been targeted against Tau protein aggregation, which include application of synthetic and natural compounds. Toluidine blue is a basic dye of phenothiazine family, which irradiation with 630 nm light con...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 89d08948-188f-5ffa-877f-ad41c8fad1f5
DOI: 10.26434/chemrxiv.8850086.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Photo-excited Toluidine Blue Inhibits Full-Length Tau Aggregation in Alzheimer’ DiseaseDOI 10.26434/chemrxiv.8850086.v1Read

Photodynamic exposure of Rose-Bengal inhibits Tau aggregation and modulates cytoskeletal network in neuronal cellsSemantic proximity Read

ThX – A next-generation probe for the early detection of amyloid aggregatesSemantic proximity Read

Inducing aggresome and stable tau aggregation in Neuro2a cells with an optogenetic toolSemantic proximity Read

Thermal cycling protects SH-SY5Y cells against hydrogen peroxide and β-amyloid-induced cell injury through stress response mechanisms involving Akt pathwaySemantic proximity Read

Two 18‐norspirostane steroidal saponins as novel mitophagy enhancers improve Alzheimer's diseaseSemantic proximity Read

Time course of Tau toxicity and pharmacologic prevention in a cell model of Tauopathy.Semantic proximity Read

Cl-NQTrp Alleviates Tauopathy Symptoms in a Model Organism through the Inhibition of Tau Aggregation-Engendered ToxicitySemantic proximity Read

Anti-tau single domain antibodies clear pathological tau and attenuate its toxicity and related functional defectsSemantic proximity Read

Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models.Semantic proximity Read

Complete phenotypic recovery of an Alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor.Semantic proximity Read

Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan.Semantic proximity Read

Novel Pentameric Thiophene Derivatives for <i>in Vitro</i> and <i>in Vivo</i> Optical Imaging of a Plethora of Protein Aggregates in Cerebral AmyloidosesSemantic proximity Read