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Article

Using Human iPSC-Derived Neurons to Model TAU Aggregation.

PloS one - 1 Jan 2015

Verheyen An, Diels Annick, Dijkmans Joyce, Oyelami Tutu, Meneghello Giulia, Mertens Liesbeth, Versweyveld Sofie, Borgers Marianne, Buist Arjan, Peeters Pieter, Cik Miroslav

Abstract excerpt

Alzheimer's disease and frontotemporal dementia are amongst the most common forms of dementia characterized by the formation and deposition of abnormal TAU in the brain. In order to develop a translational human TAU aggregation model suitable for screening, we transduced TAU harboring the pro-aggregating P301L mutation into control hiPSC-derived neural progenitor cells followed by differentiation into cortical...

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Identifiers

PMID: 26720731
DOI: 10.1371/journal.pone.0146127
PMCID: PMC4697850

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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