Article

Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay

2025-03-14

Abstract excerpt

The aggregation of tau into amyloid fibrils is associated with Alzheimer’s disease (AD) and related tauopathies. Since different tauopathies are characterised by the formation of distinct tau fibril morphologies, it is important to combine the search of tau aggregation inhibitors with the development of in vitro tau aggregation assays that recapitulate aggregation as it may occur in the brain. Here we address thi...

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Literature Corpus work: 3cb9db5b-db6c-54ee-9d20-b147f3866b57
DOI: 10.1101/2025.03.09.642189

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