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Optical induction of autophagy via Transcription factor EB (TFEB) reduces pathological tau in neurons

24 Mar 2020

Abstract excerpt

Pathological accumulation of microtubule associated protein tau in neurons is a major neuropathological hallmark of Alzheimer's disease (AD) and related tauopathies. Several attempts have been made to promote clearance of pathological tau (p-Tau) from neurons. Transcription factor EB (TFEB) has shown to clear p-Tau from neurons via autophagy. However, sustained TFEB activation and autophagy can create burden on...

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PMID: 32208437
DOI: 10.1371/journal.pone.0230026

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