Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure of the guide-strand-containing argonaute silencing complex.

Nature - 13 Nov 2008

Wang Yanli, Sheng Gang, Juranek Stefan, Tuschl Thomas, Patel Dinshaw J

Abstract excerpt

The slicer activity of the RNA-induced silencing complex is associated with argonaute, the RNase H-like PIWI domain of which catalyses guide-strand-mediated sequence-specific cleavage of target messenger RNA. Here we report on the crystal structure of Thermus thermophilus argonaute bound to a 5'-phosphorylated 21-base DNA guide strand, thereby identifying the nucleic-acid-binding channel positioned between the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA
Share to Aptamers, Nucleotide
Share to Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Silencing

Share to Hydrogen Bonding

Share to Models, Molecular

Share to Protein Structure, Tertiary

Share to Thermus thermophilus

Source

Open in PubMed Open full text

Identifiers

PMID: 18754009
DOI: 10.1038/nature07315
PMCID: PMC4689319

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure of the guide-strand-containing argonaute silencing complex.PMID 18754009Read ↗

Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes.Semantic proximity Read ↗

The Crystal Structure of Human Argonaute2Semantic proximity Read ↗

A potential protein-RNA recognition event along the RISC-loading pathway from the structure of A. aeolicus Argonaute with externally bound siRNA.Semantic proximity Read ↗

Structural and mechanistic insights into an archaeal DNA-guided Argonaute protein.Semantic proximity Read ↗

RNA-guided RNA silencing by an Asgard archaeal ArgonauteSemantic proximity Read ↗

The structural basis for RNA slicing by human Argonaute2Semantic proximity Read ↗

Structural basis for gene silencing by siRNAs in humansSemantic proximity Read ↗

Human Argonaute2 and Argonaute3 are catalytically activated by different lengths of guide RNASemantic proximity Read ↗

Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target-silencingSemantic proximity Read ↗

Structural and evolutionary determinants of Argonaute functionSemantic proximity Read ↗

Phosphorylation of human Argonaute proteins affects small RNA binding.Semantic proximity Read ↗

Lessons on RNA silencing mechanisms in plants from eukaryotic argonaute structures.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.